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KMID : 0927720100110040267
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Korean Clinical Diabetes
2010 Volume.11 No. 4 p.267 ~ p.270
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Diabetes and Alzheimer Disease
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Kim Hee-Jin
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Abstract
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Alzheimer’s disease (AD) is considered to be closely associated with neuroendocrine disorders, particularly diabetes. The association of diabetes with impaired cognitive function suggests that diabetes may contribute to AD. Recently, much epidemiologic and neurochemical evidence has been found to support these beliefs. The role of insulin is to control the release of neurotransmitters from the cell synapses, affecting the path-related signal transduction involved in learning processes and long-term memory. Postmortem brain studies have shown that insulin expression is inversely correlated with the Braak stage of dementia. Insulin signals also stop the synaptic signal transduction of amyloid-beta-derived diffusible ligands (ADDLs), reducing the synaptic plasticity of ADDLs aggravated synapse loss and oxidative damage, ultimately contributing to the hyperphosphorylation of tau and plaque formations to cause AD. Dysregulation of glucose metabolism is known to contribute to the development of both disorders, resulting in an accumulation of advanced glycation end products (AGEs). The aims of this study are to present epidemiologic data of diabetes in dementia and to review the relationship between these two diseases with regard to the pathomechanism.
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KEYWORD
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Alzheimer`s disease, Diabetes mellitus
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